Figure 3.
Effect of pharmacological inhibition of PARP on cardiac remodeling and lung weight in rat model of chronic heart failure (CHF) induced by permanent ligation of left anterior descending (LAD) coronary artery. Left ventricular (LVW), right ventricular (RVW), left atrial (LAW), right atrial (RAW) and lung (LungW) weights in sham (S), INO-1001-treated (for 10 weeks) sham (S + INO-1001), chronic heart failure (CHF) and INO-1001-treated (for 10 weeks) chronic heart failure (CHF + INO-1001) rats. Results are mean ± SEM of 8–10 experiments in each group. The weight of each cavity and lung was normalized to the length of the right tibia. *P<0.05 vs. S; #P<0.05 vs. CHF.