Figure 7.
Pharmacological inhibition of PARP with INO-1001 improves survival of mice treated with DOX. Effects of INO-1001 on survival in a DOX-induced acute (A) or chronic (B) heart failure models in mice. (A) Effect of various doses of INO-1001 (0.03, 0.3, and 3 mg/kg/day s.c.) on DOX-induced mortality (25 mg/kg IP) in mice. (B) Effect of various doses of INO-1001 (0.03, 0.3, and 3 mg/kg/day s.c.) on DOX-induced chronic mortality (3 doses of 9 mg/kg IP every 10 days) in mice. Treatment with INO-1001 (3 mg/kg) significantly decreased the DOX-induced mortality.