FIG. 2.

Stereo views of the hydrophobic pocket of VP1 and the pocket factor. (A) Averaged Fo-Fc map showing the branched electron density corresponding to a putative pocket factor that was interpreted as a ceramide. VP1 residues in the vicinity of the pocket are explicitly shown. (B) Superimposition of the ceramide molecule identified in the structures of SVDV (solid balls and sticks), the palmitic acid of the CVB3 structure (open balls and sticks) and the two WIN51711 molecules found in the structure of CVA9 (thin lines). The sphingosine moiety of the ceramide superimposes on the palmitic acid of CVB3 and one of the WIN51711 molecules. The fatty acid linked to the sphingosine moiety is partially coincident with the second WIN51711 molecule.