Bactericidal activity of anti–factor H–binding protein (fHBP) antisera against fHBP variant (v.) 1 isolates, by fHBP phenotype (n =8–21 isolates/group). A, Percentage of strains giving a titer ≥1:8; B, Reciprocal geometric mean titers (GMTs). Error bars indicate 95% confidence intervals. Shaded bars, anti–fHBP v.1 antiserum; hatched bars, anti–fHBP v.2; white bars, anti–fHBP v.3.