Bactericidal activity of anti–factor H–binding protein (fHBP) antiserum against isolates expressing fHBP variant (v.) 2 or 3. Each fHBP phenotype had 6–13 isolates. A, Percentage of strains giving a titer ≥1:8; B, Reciprocal geometric mean titers (GMTs). Error bars indicate 95% confidence intervals. Shaded bars, anti–fHBP v.1 antiserum; hatched bars, anti–fHBP v.2; white bars, anti–fHBP v.3.