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. Author manuscript; available in PMC: 2009 Jan 15.
Published in final edited form as: Dev Biol. 2007 Oct 25;313(2):876–886. doi: 10.1016/j.ydbio.2007.10.026

Figure 1.

Figure 1

eme contains multiple essential repressor sites. (A) eme sequence alignment among five Drosophila species uncovered several new regions with conserved sequences. Two repeated sets of sequences are highlighted in Red (M1 motifs) and Blue (M2 motifs), respectively. (B–D) Stage 11/12 wildtype embryos. (E–G) Stage 14 wildtype embryos. (B,E) eme-mediated lacZ expression (red) and nuclear Eve protein (green) overlap. Note lacZ but not eve expression in the Eve progenitor-derived DO2 founder (red nuclei in E). (C–G) eme with X-2 (C,F) or X-5 (D,G) region deleted, respectively. Note that these deletions expand eme enhancer activity into the entire cardiac mesoderm (see Han et al., 2002).