Table 2.
APC haplotype of kindreds with AFAP founder mutation
| Kindred | Origin | Source of Kindred | Link to founder | # tested | APC Haplotype | CEPH allele frequencies |
|---|---|---|---|---|---|---|
| K353 | Utah | Spirio et al. 6 | Yes | 3 | 3:2:5:2 | 0.37: 0.31: 0.07: 0.15 |
| K439 | New York | Spirio et al. 6 | Yes | 1 | 3:2:5:2 | 0.37: 0.31: 0.07: 0.15 |
| K3101 | Texas | Spirio et al. 6 | UNK | 2 | 3:2:5:2 | 0.37: 0.31: 0.07: 0.15 |
| K2467 | Nebraska | Spirio et al. 6 | UNK | 2 | 3:2:5:2 | 0.37: 0.31: 0.07: 0.15 |
| K37326 | Washington | PC (S. Michelson) | UNK | 1 | 3:2:5:2 | 0.37: 0.31: 0.07: 0.15 |
| K63 | Michigan | PC (W Kohlmann, S Gruber) | UNK | 2 | 3:2:5:2 | 0.37: 0.31: 0.07: 0.15 |
| K206 | Michigan | PC (W Kohlmann, S Gruber) | UNK | 3 | 3:2:5:2 | 0.37: 0.31: 0.07: 0.15 |
| K631 | Michigan | PC (W Kohlmann, S Gruber) | UNK | 1 | 3:2:5:2 | 0.37: 0.31: 0.07: 0.15 |
| K2711 | Michigan | PC (W Kohlmann, S Gruber) | UNK | 1 | 3:2:5:2 | 0.37: 0.31: 0.07: 0.15 |
| K2739 | Michigan | PC (W Kohlmann, S Gruber) | UNK | 1 | 3:2:5:2 | 0.37: 0.31: 0.07: 0.15 |
| K5254 | Michigan | PC (W Kohlmann, S Gruber) | UNK | 1 | 3:2:5:2 | 0.37: 0.31: 0.07: 0.15 |
| K19342 | Wisconsin | PC (P Levonian) | UNK | 2 | 2:2:5:2 | 0.12: 0.31: 0.07: 0.15 |
| K20536 | Wisconsin | PC (P Levonian) | UNK | 2 | 2:2:5:2 | 0.12: 0.31: 0.07: 0.15 |
| K3506 | Vermont | PC (W McKinnon) | UNK | 1 | 3:2:5:2 | 0.37: 0.31: 0.07: 0.15 |
| K3031 | Vermont | PC (W McKinnon) | UNK | 3 | 3:2:5:2 | 0.37: 0.31: 0.07: 0.15 |
| K3877 | Vermont | PC (W McKinnon) | UNK | 0 | UNK |
PC indicates personal communication. UNK indicates unknown. The # tested represents the number of kindred members with the AFAP founder mutation tested for the APC haplotype. The APC haplotype alleles are in the following order: D5S2501:D5S2027: D5S346:D5S421. The reported allele numbers and corresponding CEPH allele frequencies are based on those reported by the CEPH genotype database browser V2.1 (http://www.cephb.fr/cephdb/php/eng/index.php). The CEPH allele frequencies are based on a minimum of 27 unrelated Caucasian individuals from 8 kindreds.