FIG. 1.

Binding to MA104 cell α2β1 by laboratory-adapted rotaviruses and their reassortants. Data are for MAb AK7 relative to control MAb MOPC21 at the highest concentration used (20 μg/ml). Viruses were tested with serial twofold MAb dilutions (1.2 to 20 μg/ml) in three to five experiments. MOPC21 (1.2 to 40 μg/ml) treatment gave virus titers that were indistinguishable from titers obtained in the absence of MAb. The percent binding blockade of integrin-dependent viruses was AK7 dose dependent. Integrin-independent viruses showed no blockade at any AK7 concentration tested.