TABLE 2.

Inhibition of rotavirus infection of MA104 cells by integrin ligands collagen and fibrinogen^a

Virus	% Infectivity blockade by given ligand (mean ± SD)
	Type I collagen	Fibrinogen
Bo/NCDV	39 ± 2	29 ± 4
Si/SA11	47 ± 14	38 ± 5
Si/RRV	45 ± 4	45 ± 1
Bo/UK	−3 ± 13	−1 ± 8
Po/CRW-8	5 ± 7	−7 ± 8
Hu/Wa	51 ± 3	47 ± 5
Hu/RV-4	32 ± 8	ND
Hu/K8	35 ± 4	34 ± 4
Po/MDR-13	−9 ± 5	1 ± 7

^aData are for collagen and fibrinogen at 160 μg/ml and are expressed relative to the percent infectivity in the absence of protein. Viruses were tested by using five serial twofold dilutions of each ligand, over the range 10 to 160 μg/ml, in two to three experiments. The percent infectivity blockade of all integrin-dependent viruses was ligand dose dependent. Integrin-independent viruses UK, CRW-8, and MDR-13 showed no blockade at any ligand concentration tested. Cellular treatment with BSA (SA11, RRV, CRW-8, Wa, RV-4, K8, MDR-13) or ovalbumin (NCDV, UK) at 10 to 160 μg/ml did not inhibit infection. Virus nomenclature is the same as that used in Table 1.