Table 4.
Results of bacterial gene point mutation assay. Cerium oxide – non-nanoparticulate. Summary of mean revertant colonies obtained
| Experiment 1 | |||||||||||
| Substance | Dose Level (μg/plate) | TA100 | TA1535 | TA102 | TA98 | TA1537 | |||||
| Mean ± S.D. | Mean ± S.D. | Mean ± S.D. | Mean ± S.D. | Mean ± S.D. | |||||||
| (-S9) | (+S9) | (-S9) | (+S9) | (-S9) | (+S9) | (-S9) | (+S9) | (-S9) | (+S9) | ||
| DMSO | 100 μl | 83 ± 7 | 64 ± 5 | 40 ± 2 | 12 ± 2 | 309 ± 24 | 333 ± 29 | 21 ± 5 | 26 ± 4 | 10 ± 2 | 17 ± 3 |
| Cerium Oxide Non-nano | 50 | 85 ± 12 | 73 ± 11 | 37 ± 5 | 13 ± 1 | 333 ± 28 | 361 ± 29 | 19 ± 4 | 29 ± 2 | 12 ± 2 | 19 ± 6 |
| 150 | 96 ± 7 | 70 ± 9 | 34 ± 3 | 11 ± 2 | 341 ± 21 | 359 ± 7 | 19 ± 3 | 29 ± 3 | 13 ± 3 | 18 ± 3 | |
| 500 | 80 ± 12 | 76 ± 10 | 35 ± 7 | 11 ± 2 | 345 ± 9 | 367 ± 11 | 22 ± 7 | 29 ± 6 | 13 ± 3 | 20 ± 4 | |
| 1500 | 69 ± 10 | 75 ± 11 | 34 ± 2 | 13 ± 6 | 338 ± 10 | 350 ± 26 | 16 ± 2 | 25 ± 3 | 12 ± 5 | 21 ± 5 | |
| 5000 | 84 ± 7 | 73 ± 9 | 36 ± 3 | 10 ± 2 | 313 ± 21 | 354 ± 14 | 16 ± 4 | 31 ± 4 | 11 ± 1 | 22 ± 1 | |