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. Author manuscript; available in PMC: 2009 Jan 9.
Published in final edited form as: FEBS Lett. 2007 Nov 29;582(1):97–105. doi: 10.1016/j.febslet.2007.11.057

Figure 2. Obesity and the development of inflammation and insulin resistance.

Figure 2

Obesity-induced changes in skeletal muscle, adipose tissue and the liver result in localized inflammation and insulin resistance (IR) through autocrine and paracrine signaling. Endocrine-mediated cross-talk between insulin target tissues contributes to insulin resistance in distant tissues. Systemic inflammation and insulin resistance are the net effect of these changes.