Fig. 4.

Cell killing reaction demonstrated in the prefrontal cortical region by the cupric silver stain 24 hrs following combined treatment with memantine (20 mg/kg) and donepezil (5 mg/kg). The boxed regions in A are shown at higher magnification in B and C. Silver-stained degenerating neurons in the insular cortex and claustrum are shown in B and in the primary motor cortex in C. Scale bar = 1,000 μm in A; 100 μm in B; 50 μm in C.