Figure 2.

Clinical symptom score in patients with normal (●) and inadequate (▲) response to the 1 μg corticotropin test for each visit. The clinical score asks patients for fatigue, hypoglycemia (hypoglycemic symptoms or fasting glucose < 3,5 mmol), loss of energy, orthostatic disturbance or hypotonia (systolic blood pressure < 100 mmHg, diastolic blood pressure < 60 mmHg), reduced strength, sleep disturbance, muscle pain, mood changes (feeling depressed), nausea, concentration disturbance, weight loss (> 3 kg), stomach pain, hyperpigmentation and eosinophila (> 330 cells/ml) [9].