Figure 2.

Schematic picture of the phylogenetic relationship and the functional domains within the Adhesion GPCR family in amphioxus and human. The tree is based on a neighbor-joining tree bootstrapped 500 times. The colours of the leaves denote the species; orange for amphioxus and purple for human genes. The leaves also show the domains of the N-termini, except in two explicitly marked cases were it is C-termini that contain the domains. The domain search in amphioxus was made with the HMMER package, an e-value cut-off at 0.01 and the local PFAM models. Human domains were adopted, along with group annotations, from [13]. The symbols and abbreviations are shown in the lower left corner. The abbreviations stand for: GPS, GPCR proteolytic site; EGF, epidermal growth factor; HBD, hormone-binding domain; Ig, immunoglobulin; OLF, olfactomedin; GBL, galactose-binding lectin domain; CA, cadherin domains; LamG, laminin; LRR, leucine rich repeats; SEA, sperm protein, enterokinase, and agrin; TSP, thrombospondin; PTX, pentraxin domain. In the upper left corner are the domains unique for amphioxus. The abbreviations are: LDLa, Low-density lipoprotein receptor domain class A; SMB, Somatomedin B domain; DS, discoidin; I-set, Immunoglobulin I-set domain; CUB, CUB domain; LectinC, Lectin C-type domain; TNFR, TNFR/NGFR cysteine-rich region; Kringle, Kringle domain; SRCR, Scavenger receptor cysteine-rich domain.