Table 3.

Combined odds ratios for the two most significant SNPs in the Dutch hospital-based ORIGO cohort of breast cancer patients

SNP rs2981582 in FGFR2	SNP rs3803662 near TNRC9
	0 (wt/wt)	1 (wt/mt)	2 (mt/mt)
0 (wt/wt)	1.00	1.25 (0.87–1.78)	1.12 (0.64–1.97)
1 (wt/mt)	1.28 (0.95–1.72)	1.48 (1.06–2.05)	1.90 (1.07–3.39)
2 (mt/mt)	1.76 (1.17–2.66)	2.22 (1.37–3.60)	1.35 (0.57–3.20)

The combined effect of SNPs rs2981582 and rs3803662 on breast cancer risk was studied in the ORIGO cohort. The observed odds ratios and their 95% confidence intervals are presented. wt/wt, patients homozygous for the wildtype allele; wt/mt, patients heterozygous for the wildtype and mutated or minor allele; mt/mt, patients homozygous for the mutated or minor allele. P value for overall differences = 0.022.