Table 3.

Summary of results

Variant	Original odds for causalitya	Original conclusion	Posterior probability of pathogenicity from revised multifactorial likelihood analysis (Table 1)	Functional data (Table 2)	Conclusion
BRCA1 R1699Q	141:1	UV	54.3%	Intermediate on 1 and defective on 2 of 5 criteria	Possible low to moderate risk
BRCA1 A1708V	41:1	UV	68.8%	Intermediate on 1 and defective on 1 of 5 criteria	Possible low to moderate risk
BRCA1 A1708E	262:1	UV	99.9%	Defective on 4 of 5 criteria	High risk
BRCA1 G1738R	5,871:1	Pathogenic	96.3%	Defective on 4 of 5 criteria	High risk

^aChenevix-Trench and colleagues [5]. UV, unclassified variant.