Gain in C-statistic in three breast cancer risk prediction models with the addition of mammographic density (MD). Studies refer to Tice and colleagues [47], Barlow and colleagues [48], and Chen and colleagues [49]. Gail, Gail model; Gail 2, Gail model 2; Postmen Ext., postmenopausal extended Gail model; Premen Ext., premenopausal extended Gail model.