Table 3.
Clinicopathological parameters of the series of 295 invasive breast carcinomas together with correlation analyses of cytoplasmic and nuclear factor-inhibiting hypoxia-inducible factor-1 (FIH-1) expression
| Exclusive nuclear FIH-1 expression (n = 42) | Nuclear and cytoplasmic FIH-1 expression (n = 143) | Exclusive cytoplasmic FIH-1 expression (n = 54) | Nuclear and cytoplasmic FIH-1-negative (n = 56) | |
| Median patient age (years) | 57 | 56 | 58 | 56 |
| Median tumour size (mm) | 18 | 20 | 25 | 20 |
| Tumour grade | ||||
| 1 | 12 | 24 | 3 | 8 |
| 2 | 12 | 43 | 17 | 15 |
| 3 | 8 | 35 | 21 | 12 |
| Nodal status | ||||
| Negative | 23 | 77 | 32 | 35 |
| Positive | 19 | 64 | 22 | 20 |
| Oestrogen receptor status | ||||
| Negative | 8 | 30 | 14 | 20 |
| Positive | 34 | 113 | 40 | 35 |
| Human epidermal growth factor receptor 2 status | ||||
| Negative | 25 | 95 | 43 | 23 |
| Positive | 3 | 17 | 6 | 2 |
| Hypoxia-inducible factor 1α | ||||
| Negative | 10 | 41 | 25 | 22 |
| Positive | 32 | 82 | 28 | 20 |
| Carbonic anhydrase 9 | ||||
| Negative | 34 | 111 | 33 | 22 |
| Positive | 3 | 14 | 11 | 4 |
| Recurrence | ||||
| Negative | 32 | 88 | 28 | 37 |
| Positive | 9 | 54 | 26 | 18 |
n < 295 data not available.