Table 1.
Excluded studies examining antifungal prophylaxis in adult non-neutropenic patients (n = 24)
| Reference | Year | Endpoint | Exclusion | Design |
| Stoutenbeek et al. [41] | 1984 | SDD in ICU patients | Only yeast as percentage of cultures | Cohort |
| Slotman et al. [42] | 1988 | Ketoconazole prophylaxis in ALI/ARDS | No yeast scored | RCT |
| Flaherty et al. [43] | 1990 | SDD in ICU patients | No yeast scored | RCT |
| Godard et al. [44] | 1990 | SDD in ICU patients | No yeast scored (+ no control group) | RCT |
| Rodriguez-Roldán et al. [45] | 1990 | SDD in ICU patients | No yeast scored | RCT |
| Tetteroo et al. [46] | 1990 | SDD in oesophageal resection | No yeast scored | RCT |
| Gastinne et al. [47] | 1992 | SDD in ICU patients | No yeast scored | RCT |
| Jacobs et al. [48] | 1992 | SDD in ICU patients | No yeast scored | RCT |
| Rocha et al. [49] | 1992 | SDD in ICU patients | No yeast scored | RCT |
| Korinek et al. [50] | 1993 | SDD in neurosurgical ICU patients | Only yeast as percentage of cultures | RCT |
| Yu and Tomasa [51] | 1993 | Ketokonazole prophylaxis in ARDS | No yeast scored | RCT |
| Misset et al. [52] | 1994 | SDD in ICU patients | No control group | RCT |
| Sorkine et al. [53] | 1996 | Amphotericin B treatment in Candida sepsis | No control group | RCT |
| Lingnau et al. [54] | 1997 | SDD in multiple trauma patients | No yeast scored | RCT |
| Palomar et al. [55] | 1997 | SDD in ICU patients | No yeast scored | RCT |
| Safran and Dawson [56] | 1997 | Fluconazole prophylaxis in SICU patients | Retrospective (+ no control group) | Cohort |
| Schardey et al. [57] | 1997 | SDD in total gastrectomy | Only yeast as percentage of cultures | RCT |
| Sánchez García et al. [58] | 1998 | SDD in ICU patients | Only yeast as percentage of cultures | RCT |
| ARDS network [59] | 2000 | Ketoconazole prophylaxis in ALI/ARDS | No yeast scored | RCT |
| Pneumatikos et al. [60] | 2002 | Subglottal decontamination | No yeast scored | RCT |
| De Waele et al. [61] | 2003 | Fluconazole prophylaxis in pancreatitis | Retrospective | Cohort |
| Swoboda et al. [62] | 2003 | Fluconazole prophylaxis in SICU patients | Retrospective | Cohort |
| Magill et al. [63] | 2004 | Fluconazole prophylaxis in SICU patients | No yeast scored | RCT |
| Shan et al. [64] | 2006 | Early presumptive therapy in GI surgery | Retrospective | Cohort |
Reasons for exclusion: no yeast outcomes reported (n = 14), only yeast as percentage of cultures (n = 4), no control group (n = 2), retrospective design (n = 4). ALI, acute lung injury; ARDS, acute respiratory distress syndrome; GI, gastrointestinal; ICU, intensive care unit; RCT, randomised controlled trial; SDD, selective decontamination of the digestive tract; SICU, surgical intensive care unit.