Impact of different variables on the acid-base state during induction of shock. Values (mean ± standard error of the mean) (n = 8) are presented as the difference between the time points of baseline and shock. A negative value represents an increase in anionic components or a decrease in cationic components, corresponding to an acidifying effect, and a positive value represents an increase in cationic or a decrease in anionic components, corresponding to an alkalinizing effect. Asterisk indicates unidentified anions that are still missing. Ace-, serum concentration of acetate; AG, anion gap; Alb-, negative electric charges contributed by albumin; Ca2+, serum equivalents of calcium; Cit3-, serum equivalents of citrate; Cl-, serum concentration of chloride; K+, serum concentration of potassium; Lac-, serum concentration of lactate; Mg2+, serum equivalents of magnesium; Na+, serum concentration of sodium; Pi-, negative electric charges contributed by inorganic phosphate; SIG, strong ion gap; SO42-, serum equivalents of sulfate.