Table 1.
Measured and calculated values of the acid-base status
| Time point of measurement | ||||||
| Baseline | Shock | Immediately after therapy | 30 minutes after therapy | 60 minutes after therapy | 180 minutes after therapy | |
| pH | 7.41 ± 0.01 | 7.19 ± 0.02a | 7.13 ± 0.02a | 7.23 ± 0.01a | 7.27 ± 0.01a | 7.26 ± 0.01a |
| pCO2, torr | 33.4 ± 1.4 | 32.5 ± 2.6 | 43.8 ± 2.6a | 39.4 ± 1.5a | 36.4 ± 2.1 | 33.8 ± 1.0 |
| sBE, mEq/L | -3.2 ± 0.5 | -15.0 ± 1.0a | -14.7 ± 0.6a | -10.8 ± 0.7a | -9.5 ± 0.6a | -11.2 ± 0.4a |
| Na+, mEq/L | 149 ± 0.9 | 150 ± 0.9 | 150 ± 0.9 | 150 ± 1.2 | 151 ± 1.2 | 152 ± 1.9 |
| K+, mEq/L | 3.8 ± 0.3 | 3.7 ± 0.3 | 3.9 ± 0.3 | 4.4 ± 0.3 | 4.5 ± 0.3 | 4.5 ± 0.3 |
| Ca2+, mEq/L | 3.7 ± 0.1 | 3.3 ± 0.2 | 3.3 ± 0.1a | 3.2 ± 0.1a | 3.3 ± 0.1a | 3.4 ± 0.1 |
| Mg2+, mEq/L | 1.2 ± 0.1 | 1.5 ± 0.1 | 1.3 ± 0.1 | 1.3 ± 0.1 | 1.3 ± 0.1 | 1.2 ± 0.1 |
| Cl-, mEq/L | 130 ± 1.7 | 130 ± 1.9 | 134 ± 2.1 | 136 ± 1.1 | 139 ± 1.5a | 145 ± 1.8a |
| Lac-, mEq/L | 1.5 ± 0.2 | 5.5 ± 0.9a | 5.6 ± 0.7a | 3.7 ± 0.5a | 2.3 ± 0.4 | 2.5 ± 0.5 |
| SIDa, mEq/L | 26.1 ± 1.0 | 24.3 ± 1.5 | 19.9 ± 2.0a | 19.0 ± 0.5a | 19.3 ± 1.6a | 15.6 ± 1.2a |
| PO4-, mEq/L | 2.5 ± 0.2 | 3.0 ± 0.2 | 3.2 ± 0.2 | 3.4 ± 0.3 | 3.2 ± 0.4 | 2.6 ± 0.2 |
| Alb, g/dL | 1.5 ± 0.2 | 1.1 ± 0.1a | 0.7 ± 0.1a | 0.7 ± 0.1a | 0.7 ± 0.1a | 0.5 ± 0.1a |
| SIDe, mEq/L | 27.8 ± 0.9 | 19.2 ± 0.7a | 19.3 ± 0.4a | 21.6 ± 1.0a | 21.6 ± 1.0a | 19.6 ± 0.4a |
| SIG, mEq/L | -2.0 ± 1.5 | 5.1 ± 2.2a | 0.6 ± 2.0 | -2.6 ± 1.3 | -2.2 ± 1.4 | -2.9 ± 1.5 |
| AG, mEq/L | 3.1 ± 1.2 | 14.1 ± 3.3a | 5.8 ± 1.6 | 2.1 ± 1.2 | 0.0 ± 1.0 | -0.2 ± 1.3 |
| AGcorr, mEq/L | 7.8 ± 1.6 | 18.6 ± 2.9a | 8.8 ± 1.8 | 6.9 ± 1.0 | 6.6 ± 1.0 | 5.5 ± 1.2 |
Data are presented as mean ± standard error of the mean (n = 8). ap < 0.05 with respect to baseline. AG, anion gap; AGcorr, corrected anion gap; Alb, serum concentration of albumin; Ca2+, plasma concentration of calcium; Cl-, plasma concentration of chloride; K+, plasma concentration of potassium; Lac-, plasma concentration of lactate; Mg2+, plasma concentration of magnesium; Na+, plasma concentration of sodium; pCO2, arterial carbon dioxide partial pressure; PO4-, serum concentration of phosphate; sBE, standard base excess; SIDa, apparent strong ion difference; SIDe, effective strong ion difference; SIG, strong ion gap.