Table 7.

Effect of Hfe disruption on plasma lipid profiles

	C57BL/6 strain			DBA/2 strain
	Hfe-/-	Hfe+/+	P	Hfe-/-	Hfe+/+	P
Total cholesterol (mg/ml)	0.93 ± 0.24	1.07 ± 0.05	0.28	1.46 ± 0.25	1.17 ± 0.13	0.04
HDL-cholesterol (mg/ml)	0.71 ± 0.18	0.86 ± 0.05	0.16	1.14 ± 0.11	0.97 ± 0.08	0.02

Hfe^-/- and Hfe^+/+ mice (five males per group) were killed at age 7 weeks. Blood was removed and plasma lipid levels were determined by chromatography. Results are expressed as mean ± standard deviation in each group. P values for comparisons of plasma lipid levels between Hfe^-/- and Hfe^+/+ mice of each strain were obtained by Student's t-test. HDL, high-density lipoprotein.