Table 6.

Functional TFBS constraints used in the promoter simulation

Name	Accession no.	Length (bp)	Strand	Location (min, max)	Copy no. (min, max)	Cutoff
YY1E2F	MA0095 (YY1) MA0024 (E2F)	13	+	(20, 30)	(1, 1)	0.90
Pax6	MA0069	14	+	(50, 70)	(1, 1)	0.90
TP53	MA0106	20	+	(360, 400)	(1, 1)	0.90
IRF2	MA0051	18	+	(420, 480)	(1, 1)	0.90
PPARG	MA0066	20	+	(2000, 2080)	(1, 1)	0.90
ROAZ	MA0116	15	+	(2100, 2200)	(1, 1)	0.90

The accession numbers in the second column are from the JASPAR database [39]. 'Location' refers to the restriction on the upstream minimum and maximum distances to transcription start site. YY1E2F is a composite TFBS created by joining the YY1 and E2F sites.