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Reaction profile and conformational dynamics of dihydrofolate reductase. The free energy profile of the hydride transfer reaction is shown as a function of a collective reaction coordinate, which includes motions of the enzyme, substrate and cofactor in the dihydrofolate-reductase-catalysed reaction. The donor–acceptor distance is shown next to each structure. Reprinted with permission from Sergi et al (2006). ©2006 American Chemical Society.
