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Dorsal ruffles. (A) Cultured human pancreatic tumour cells internalize epidermal growth factor receptor (red) at sites positive for dynamin 2 (green), dorsal ruffles or circular lamellipodia. (B) Platelet-derived growth factor stimulates similar structures in fibroblasts, which are positive for actin-related protein 2/3 complex (green) and actin (red). Images are kindly provided by M. McNiven (A) and J.A. Legg and L. Machesky (B). Scale bars, 10 μm.
