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. 2008 Jan;9(1):42–49. doi: 10.1038/sj.embor.7401126

Figure 2.

Figure 2

Mitochondrial intermembrane space import and assembly machinery. Precursors of small intermembrane space (IMS) proteins are translocated through the TOM complex and bound by Mia40 through disulphide bonds. The sulphydryl oxidase Erv1 cooperates with Mia40 in the oxidation of precursor proteins and their assembly into oligomeric complexes. Further factors such as Hot13 support assembly of the protein complexes. Erv1, Essential for respiration and viability 1; Hot13, Helper of TIM13; Mia40, mitochondrial intermembrane space import and assembly; TIM, translocase of the inner membrane; TOM, translocase of the outer membrane.