Table 1.
groucho alleles for which molecular data were obtainable
| Type of lesion | Allele | Base change* | RNA/protein changes |
|---|---|---|---|
| Nonsense | |||
| MBB | G4624A | W550stop | |
| MB6 | C2315T | R190stop | |
| MB11 | C4769T | Q599stop | |
| MB25 | C4361T | Q463stop, as MB27 | |
| MB27 | C4361T | Q463stop, as MB25 | |
| MB34 | G4749A | W592stop | |
| MB42 | G4716A | W581stop | |
| Frameshift | |||
| MB13 | G2485A | Splice junction mutated, frameshift from residue 225 as intronic sequences transcribed, as MB37 | |
| MB15 | G138A | Ectopic splice acceptor site in intron, frameshift from residue 13, as MB36 | |
| MB18 | G266A | Splice junction mutated, frameshift from residue 45 as intronic sequences transcribed | |
| MB33 | Δ3782–3813 | 31 bp deletion; frameshift from residue 103 | |
| MB36 | G138A | as MB15 | |
| MB37 | G2485A | as MB13 | |
| Other | |||
| MB5 | T189C | P19S, Δ19–27 | |
| C190T | See Fig 2B for sequence | ||
| Δ191–214 | |||
| MB12 | G3A | Initiator ATG → ATA | |
| Missense† | |||
| MBD | A4613T | I547F | |
| MB19 | G4683A | C570Y | |
| MB21 | G4422A | R483H, as MB41 | |
| MB30 | A4977C | H646P | |
| MB31 | C5176T | L692F | |
| MB35 | G4326A | G451D | |
| MB41 | G4422A | R483H, as MB21 | |
| *Bases numbered from the start of translation, corresponding to 3R:21869066 Drosophila melanogaster genome Release 5.1. | |||
| †For characterization of missense alleles, refer to Jennings et al (2006). | |||