Table 1.
Proteins associated with human AGO1 and AGO2
| Name | Domains/motif | AGO1 complex | AGO2 complex | Accession no. |
|---|---|---|---|---|
| Proteins involved in gene silencing | ||||
| Dicer | DEAD box, RNase III, PAZ, dsRBD, DUF | I, III | I, III* | gi∣21665773/gi∣5019620 |
| TNRC6B | RRM | — | I | gi∣14133235 |
| MOV10 | DExH box | III | III | gi∣14424568 |
| TRBP | dsRBD | I* | I* | gi∣107904 |
| Gemin3 | DEAD box | II* | gi∣14209614 | |
| Gemin4 | Leucin zipper | II*, III | II, III | gi∣7657122 |
| DEAD/DEAH box-containing proteins | ||||
| RNA helicase A (RHA)/DHX9 | DEAH box, helicase domain, dsRBD, DUF1605 | II, III | II, III | gi∣1806048/gi∣1082769 |
| DHX30 | DEAH box, helicase domain, dsRBD, DUF1605 | II, III | II, III | gi∣20336294 |
| RENT1/Upf1 | DEAD box, exoV | III | — | gi∣1575536 |
| DHX36 | DEAH box, helicase domain, DUF1605 | II*, III* | II* | gi∣7959237/gi∣23243423 |
| DDX21/RNA helicase GuA | DEAD box, helicase domain, GUCT | II, III | II | gi∣2135315 |
| DDX50/RNA helicase GuB | DEAD box, helicase domain, GUCT, RESIII | III | — | gi∣55664207 |
| DDX46 | DEAH box, helicase domain, DUF1605 | II* | II* | gi∣2696613 |
| DDX48 | DEAD box, helicase domain | II*, III | — | gi∣496902 |
| DDX18 | DEAD box, helicase domain | III | — | gi∣1498229 |
| DDX5/p68 | DEAD box, helicase domain | — | II* | |
| DDX39/BAT1 | DEAD box, helicase domain | III* | II* | gi∣1905998 |
| DDX47 | DEAD box, helicase domain, apolipoprotein L | III | — | gi∣20149629 |
| Heterogeneous nuclear ribonucleoprotein particles | ||||
| hnRNP-U | SAP, SPRY, SCOP | II, III | II, III | gi∣32358 |
| hnRNP-U-like | SAP, SPRY, SCOP | I* | — | gi∣3319956 |
| hnRNP-H2/H' | RRM, RNPHF zinc finger | II* | — | gi∣6065880 |
| hnRNP-F | RRM, RNPHF zinc finger | II* | I* | gi∣16876910 |
| hnRNP-C | RRM | II, III | II, III | gi∣13937888/gi∣14250048 |
| hnRNP-E2 | KH1, KH2 | III* | — | |
| NSAP1 | Phox-like, PX-associated motif, RRM | II, III | — | gi∣5031512 |
| hnRNP-L | Enoyl-CoA hydratase/isomerase, RRM | III* | — | gi∣11527777 |
| Messenger RNA-binding proteins | ||||
| Poly-A-binding proteins | RRM | II, III | II, III | gi∣46367787/gi∣693937 |
| Nuclear cap-binding protein 80 kDa | MIF4G | III | — | gi∣3153873 |
| YB-1 | Cold-shock domain | II | II, III | gi∣181486/gi∣55451 |
| FMRp | Agenet, KH1 | III* | — | gi∣182673 |
| FXR1 | Agenet, KH1 | — | III | gi∣1730139 |
| FXR2 | Agenet, KH1 | III | — | gi∣4758410 |
| ZBP-1 | RRM, KH1 | II, III | III | gi∣7141072/gi∣56237027 |
| ZBP-3 | RRM, KH1 | III | — | gi∣30795212 |
| HuR | RRM | III* | — | gi∣1022961 |
| RBM4 | RRM, zinc finger | — | III* | gi∣4506445 |
| Proteins involved in RNA metabolism | ||||
| NF90/ILF3/NFAR-1 | dsRBD, DZF | II, III | II | gi∣1082856/gi∣5006602 |
| NF45/ILF2 | DZF | II, III | II, III | gi∣532313 |
| SART3 | Lsm interaction motif, RRM | I, II, III | — | gi∣7661952 |
| RBM10 | D111/G-patch, RRM, zinc finger, Ran binding | — | I*, II* | gi∣12644371 |
| Fibrillarin | Fibrillarin motif | — | II*, III* | gi∣182592 |
| NOP56 | Pre-mRNA processing RNP, NOP5NT, NOSIC | III | — | gi∣2230878 |
| Nucleolin | RRM | III | — | gi∣128841 |
| eIF2bδ | Initiation factor 2B | I* | — | gi∣6563202 |
| eIF4b | RRM | — | I* | gi∣288100 |
| FLJ20758 | Pentatricopeptide repeat | II | II | gi∣38683855 |
| Other proteins | ||||
| Myb-binding protein 1a | DNA polymerase V | III | III* | gi∣7657351 |
| Matrin 3 | RRM, zinc finger | III* | III* | gi∣6563246 |
| Motor protein | — | II, III | gi∣516764 | |
| ZNF326 | AKAP95 | II, III | — | gi∣31807861/gi∣47125447 |
| Ku70 | Ku70/80 motif, DNA-binding SAP | — | II* | gi∣57165052 |
| DDB1 | CPSF A subunit | I | I* | gi∣418316 |
| RuvB-like II | AAA ATPase, Tip49b | I | I, II | gi∣5730023/gi∣12653319 |
| Coatomer protein | WD-40, COPB2 | III | II | gi∣1002369 |
| *Identified by a single peptide. | ||||