Figure 2.
Quadruplex polymorphism. Examples of intramolecular G-quadruplexes with different folding and capping structures. Intramolecular G-quadruplex structures are all derived from a single-stranded DNA (top). The conformational diversity suggests that these G-quadruplex structures might be specifically recognized by various proteins and small molecule ligands. c-myc reprinted with permission from Ambrus et al (2005), copyright 2005 American Chemical Society; bcl-2 reprinted with permission from Dai et al (2006b); hTel-1 reprinted with permission from Dai et al (2007b); hTel-2 reprinted with permission from Dai et al (2007a).