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Steady level of InsP3R channel activity observed after channel activation by abrupt jumps in ligand concentration. (A) Current traces of InsP3R channels after activation by step change in [InsP3] (top), [Ca2+]i (middle) and both simultaneously (bottom). (B) Averaged time course of Po (in 0.1 s bins) of one InsP3R channel after step change of [Ca2+]i at t=0 in one membrane patch. A total of 72 [Ca2+]i jumps were averaged. InsP3R, inositol 1,4,5-trisphosphate receptor.
