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. 2008 Jan 11;9:16. doi: 10.1186/1471-2105-9-16

Table 1.

Prediction in biological assessment. Summary of the light and heavy chain and sex prediction obtained for 47 new patients.

Patient Sex Light chain Heavy chain
NS errors PAM score File NS errors PAM score File NS errors PAM score File
F M P F M P κ λ P κ λ P A G P A G P
E4006 11 0 M 0.000 1.000 M M 9 3 λ 0.000 1.000 λ λ 9 1 G 1.000 0.000 A A
E4020 0 10 F 0.168 0.832 M F 11 1 λ 0.000 1.000 λ λ 23 0 G 0.000 1.000 G G
E4038 0 10 F 1.000 0.000 F F 0 64 κ 1.000 0.000 κ κ Light chain myeloma
E4049 0 10 F 0.000 1.000 M F 0 52 κ 1.000 0.000 κ κ Light chain myeloma
E4050 11 10 MY- 0.000 1.000 MY- MY- 1 50 κ 1.000 0.000 κ κ 15 0 G 0.000 1.000 G G
E4054 11 0 M 0.000 1.000 M M 0 48 κ 0.903 0.097 κ κ 41* 61* A 0.077 0.923 G A
E4055 11 0 M 0.000 1.000 M M 23 0 λ 0.000 1.000 λ λ 56 1 G 0.000 1.000 G G
E4056 0 10 F 1.000 0.000 F F 0 55 κ 1.000 0.000 κ κ 1 2 A 1.000 0.000 A A
E4057 11 0 M 0.000 1.000 M M 7 3 λ 0.008 0.992 λ λ 29 0 G 0.995 0.005 A G
E4060 11 0 M 0.000 1.000 M M 0 35 κ 1.000 0.000 κ κ 48 0 G 0.000 1.000 G G
E4067 11 0 M 0.000 1.000 M M 0 50 κ 1.000 0.000 κ κ 57 0 G 0.000 1.000 G G
E4071 11 0 M 0.000 1.000 M M 0 51 κ 1.000 0.000 κ κ 59 0 G 0.000 1.000 G G
E4073 0 10 MY- 0.000 1.000 MY- MY- 0 58 κ 1.000 0.000 κ κ 48 0 G 0.000 1.000 G G
E4078 0 10 F 0.000 1.000 M F 8 1 λ 0.000 1.000 λ λ IgD myeloma
E4085 0 10 F 0.001 0.999 M F 15 2 λ 0.003 0.997 λ λ Light chain myeloma
E4094 11 0 M 0.000 1.000 M M 0 51 κ 0.770 0.230 κ κ 0 17 A 0.254 0.746 G A
E4105 0 10 F 0.000 1.000 M F 6 3 λ 0.000 1.000 λ λ Light chain myeloma
E4106 0 10 F 0.996 0.004 F F 0 42 κ 0.997 0.003 κ κ 0 5 A 0.065 0.935 G A
E4121 0 10 F 0.000 1.000 M F 27 0 λ 0.000 1.000 λ λ 27 0 G 0.000 1.000 G G
E4122 11 10 MY- 0.000 1.000 MY- MY- 0 59 κ 0.999 0.001 κ κ 0 16 A 1.000 0.000 A A
E4126 11 0 M 0.000 1.000 M M 0 50 κ 0.983 0.017 κ κ 0 17 A 1.000 0.000 A A
E5007 0 10 F 0.000 1.000 M F 0 32 κ 1.000 0.000 κ κ 2 3 A 0.291 0.709 G A
E5024 11 0 M 0.000 1.000 M M 0 51 κ 0.999 0.001 κ κ IgD myeloma
E5029 0 10 F 0.000 1.000 M F 28 0 λ 0.000 1.000 λ λ Light chain myeloma
E5035 0 10 F 1.000 0.000 F F 0 56 κ 0.994 0.006 κ κ 52 0 G 0.000 1.000 G G
E5038 11 10 MY- 0.000 1.000 MY- MY- 0 59 κ 0.974 0.026 κ κ Light chain myeloma
E5040 0 10 F 0.001 0.999 M F 1 38 κ 0.998 0.002 κ κ 96* 43* G 0.000 1.000 G G
E5043 0 10 F 0.001 0.999 M F 0 48 κ 0.994 0.006 κ κ 45 0 G 0.000 1.000 G G
E5046 0 10 F 0.000 1.000 M F 28 0 λ 0.000 1.000 λ λ 0 19 A 1.000 0.000 A A
E5048 11 0 M 0.000 1.000 M M 25 0 λ 0.000 1.000 λ λ 17 0 G 0.000 1.000 G G
E5049 0 10 F 0.001 0.999 M F 1 48 κ 0.996 0.004 κ κ 52 0 G 0.000 1.000 G G
E5065 11 0 M 0.000 1.000 M M 25 0 λ 0.001 0.999 λ λ Light chain myeloma
E5066 0 10 F 0.000 1.000 M F 28 0 λ 0.008 0.992 λ λ Light chain myeloma
E5068 0 10 F 0.000 1.000 M F 16 0 λ 0.122 0.878 λ λ 0 17 A 0.875 0.125 A A
E5069 0 10 F 0.001 0.999 M F 0 62 κ 0.695 0.305 κ κ 104* 44* G 0.000 1.000 G G
E5081 0 10 F 0.000 1.000 M F 26 0 λ 0.212 0.788 λ λ 33 0 G 0.000 1.000 G G
E5084 11 10 MY- 0.000 1.000 MY- MY- 23 0 λ 0.088 0.912 λ λ 0 18 A 0.019 0.981 G A
E5087 0 10 F 1.000 0.000 F F 0 61 κ 0.912 0.088 κ κ 55 0 G 0.000 1.000 G G
E5093 0 10 F 0.999 0.001 F F 1 35 κ 0.978 0.022 κ κ 43 0 G 0.000 1.000 G G
E5103 0 10 F 1.000 0.000 F F 1 39 κ 0.997 0.003 κ κ 47 0 G 0.000 1.000 G G
E5104 11 0 M 0.000 1.000 M M 0 51 κ 0.927 0.073 κ κ Light chain myeloma
E5106 0 10 F 0.002 0.998 M F 0 58 κ 0.873 0.127 κ κ 0 7 A 0.552 0.448 A A
E5125 11 0 M 0.000 1.000 M M 3 13 κ 0.841 0.159 κ κ 5 1 G 0.000 1.000 G G
E5126 11 10 MY- 0.000 1.000 MY- MY- 0 38 κ 0.236 0.764 λ κ 9 0 G 0.000 1.000 G G
E5136 0 10 F 1.000 0.000 F F 0 59 κ 0.391 0.609 λ κ Light chain myeloma
E5138 11 0 M 0.000 1.000 M M 17 1 λ 0.000 1.000 λ λ Light chain myeloma
E5139 0 10 F 0.003 0.997 M F 11 1 λ 0.000 1.000 λ λ 21 0 G 0.000 1.000 G G
E6002 11 0 M 0.000 1.000 M M 0 46 κ 0.958 0.042 κ κ Light chain myeloma
E6003 11 0 M 0.000 1.000 M M 0 53 κ 0.975 0.025 κ κ 44* 65* A 0.855 0.145 A A
E6008 11 0 M 0.000 1.000 M M 0 26 κ 0.891 0.109 κ κ 29 1 G 0.000 1.000 G G
E6011 11 0 M 0.000 1.000 M M 0 56 κ 0.975 0.025 κ κ 49 0 G 0.000 1.000 G G
E6020 11 10 MY- 0.000 1.000 M F 16 0 λ 0.000 1.000 λ λ 6 0 G 0.000 1.000 G G
E6022 0 10 F 1.000 0.000 F F 0 39 κ 1.000 0.000 κ κ 0 4 A 1.000 0.000 A A
E6024 11 0 M 0.000 1.000 M M 10 1 λ 0.000 1.000 λ λ IgD myeloma
E6025 11 0 M 0.000 1.000 M M 4 13 κ 0.003 0.997 λ κ 30 1 G 1.000 0.000 A G
E6026 0 10 F 0.001 0.999 M F 0 27 κ 1.000 0.000 κ κ 36 0 G 0.000 1.000 G G
E6049 11 0 M 0.000 1.000 M M 0 12 κ 1.000 0.000 κ κ 2 4 A 0.008 0.992 G A
E6054 11 0 M 0.000 1.000 M M 0 40 κ 1.000 0.000 κ κ 3 8 A 0.002 0.998 G A
E6056 11 0 M 0.000 1.000 M M 0 37 κ 1.000 0.000 κ κ 0 6 A 1.000 0.000 A A
E6063 11 10 MY- 0.000 1.000 MY- MY- 1 13 κ 0.999 0.001 κ κ 8 1 G 0.000 1.000 G G
E6074 11 0 M 0.000 1.000 M M 0 22 κ 1.000 0.000 κ κ Light chain myeloma
E6077 11 0 M 0.000 1.000 M M 1 31 κ 1.000 0.000 κ κ 51 0 G 0.000 1.000 G G
E6087 0 10 F 0.002 0.998 M F 15 1 λ 0.000 1.000 λ λ 0 8 A 1.000 0.000 A A
E6092 0 10 F 1.000 0.000 F F 17 1 λ 0.000 1.000 λ λ 67* 50* G 0.000 1.000 G G
E6100 0 10 F 1.000 0.000 F F 1 25 κ 0.477 0.523 λ κ 70* 44* G 0.000 1.000 G G
E6108 0 10 F 1.000 0.000 F F 0 46 κ 1.000 0.000 κ κ Light chain myeloma
E6117 0 10 F 0.009 0.991 M F 13 1 λ 0.001 0.999 λ λ Light chain myeloma
E6120 11 0 M 0.000 1.000 M M 16 2 λ 0.000 1.000 λ λ 0 2 A 1.000 0.000 A A

Abbreviations:

F: female, M: male

P: predicted

MY-: male with Y chromosome deletion

A: IgA, G: IgG

*: When the number of non significant comparisons is identical in both classes for the call predictor at a given precision of the Bonferroni-corrected χ2 sample-to-sample comparisons, the P-value is increased by one log unit, adding intra-class errors to interclass ones, but still leading to a correct classification.