Table 5.
PDB | Size | Weight | Stat. | Nmin | p-value | FDR | 3D dist. | 3D p-value |
ARG147, ASP187 | 2 | Unweighted | 0.57 | 4.92 | 0*** | yes | 6.24 | 0.001*** |
ARG147, ASP187 | 2 | Grantham | 0.59 | 517.54 | 0*** | yes | 6.24 | 0.001*** |
ARG147, ASP187 | 2 | Volume | 0.58 | 384.76 | 3e-04*** | yes | 6.24 | 0.001*** |
GLN154, GLU158 | 2 | Unweighted | 0.65 | 4.93 | 0*** | yes | 5.96 | 0.001***‡ |
GLN154, GLU158 | 2 | Charge | 0.67 | 4.1 | 1e-04*** | yes | 5.96 | 0.001***‡ |
GLY122, LEU230 | 2 | Unweighted | 0.6 | 6.42 | 1e-04*** | yes | 7.44 | 0.002**‡ |
GLY122, LEU230 | 2 | Grantham | 0.6 | 590.32 | 1e-04*** | yes | 7.44 | 0.002**‡ |
GLY122, LEU230 | 2 | Polarity | 0.61 | 18.34 | 1e-04*** | yes | 7.44 | 0.002**‡ |
GLY122, LEU230 | 2 | Volume | 0.48 | 275.16 | 0.0052** | yes | 7.44 | 0.002**‡ |
ALA21, LEU25, GLY107 | 3 | Unweighted | 0.45 | 4.09 | 1e-04*** | yes | 12.07 | 0.001*** |
LEU25, GLY107 | 2 | Grantham | 0.52 | 312.81 | 0.0077** | no | 12.07 | 0.031* |
THR241, GLY244 | 2 | Unweighted | 0.57 | 3.24 | 3e-04*** | yes | 5.11 | 0.001*** |
ASN46, SER68 | 2 | Unweighted | 0.48 | 4.67 | 5e-04*** | yes | 5.92 | 0.001*** |
GLY210, THR225 | 2 | Unweighted | 0.56 | 3.25 | 5e-04*** | yes | 8.28 | 0.004** |
ASP219, TRP221, THR222, THR225, ASP227, GLU235, ILE238, THR241, LEU248 | 9 | Grantham | 0.3 | 68.81 | 6e-04*** | yes | 40.12 | 0.2338† |
TRP221, THR222 | 2 | Unweighted | 0.57 | 2.73 | 0.0014** | yes | 3.75 | 0.001***† |
TRP221, THR225, | 3 | Volume | 0.56 | 105.03 | 0.0092** | no | 18.13 | 0.024*† |
ASP227 | ||||||||
LEU125, THR129 | 2 | Unweighted | 0.53 | 3.21 | 6e-04*** | yes | 6.12 | 0.001*** |
ASN208, SER231 | 2 | Unweighted | 0.48 | 4.32 | 7e-04*** | yes | 4.25 | 0.001*** |
TRP221, THR222, ALA232, GLU235, ILE238, VAL239, THR241, ILE247, LEU248 | 9 | Polarity | 0.28 | 2.15 | 0.001*** | yes | 34.73 | 0.025* |
GLU148, GLU190 | 2 | Unweighted | 0.48 | 5.11 | 0.0011** | yes | 11.88 | 0.03* |
GLU148, GLU190 | 2 | Polarity | 0.5 | 13.91 | 0.006** | yes | 11.88 | 0.03* |
GLY210, GLY244, GLU246 | 3 | Grantham | 0.43 | 302.15 | 0.0012** | yes | 33.45 | 0.4945 |
CYS78, ASN95, SER110, GLY150, GLN233 | 5 | Unweighted | 0.24 | 2.48 | 0.0018** | yes | 21.37 | 0.001*** |
CYS169, GLN182 | 2 | Unweighted | 0.45 | 4.39 | 0.0018** | yes | 6.4 | 0.002** |
ILE96, TYR134 | 2 | Unweighted | 0.49 | 5.96 | 0.002** | yes | 18.27 | 0.1768 |
ILE81, PHE113 | 2 | Unweighted | 0.45 | 4.33 | 0.0021** | yes | 16.36 | 0.1259 |
ASP227, ALA232, GLU235 | 3 | Unweighted | 0.48 | 1.41 | 0.0022** | yes | 23.49 | 0.0949. |
ASP219, VAL223 | 2 | Unweighted | 0.46 | 3.66 | 0.0024** | yes | 9.4 | 0.009** |
HIS63, ARG127, GLN130, ALA209 | 4 | Volume | 0.33 | 205.12 | 0.0032** | yes | 32.09 | 0.2527 |
HIS63, GLN130 | 2 | Charge | 0.47 | 5.36 | 0.0035** | yes | 28.75 | 0.5994 |
THR222, SER231, ILE238, VAL239 | 4 | Charge | 0.71 | 0.99 | 0.0039** | yes | 28.93 | 0.1199 |
ARG124, GLU131 | 2 | Grantham | 0.48 | 461.88 | 0.0043** | yes | 10.6 | 0.016* |
GLU131, VAL157, VAL164 | 3 | Unweighted | 0.36 | 4.39 | 0.0045** | yes | 13.43 | 0.001*** |
GLN53, VAL98 | 2 | Grantham | 0.48 | 409.37 | 0.0049** | yes | 13.51 | 0.0579. |
GLU29, VAL32, ILE81, PRO82, THR129, ALA136, ILE149, GLY150, SER163 | 9 | Polarity | 0.21 | 0.1 | 0.005** | yes | 32.31 | 0.008** |
LEU135, PHE156 | 2 | Grantham | 0.49 | 575.88 | 0.0052** | yes | 8.71 | 0.004** |
GLN53, GLU160 | 2 | Charge | 0.44 | 5.85 | 0.0055** | yes | 39.55 | 0.9311 |
VAL56, ILE101 | 2 | Unweighted | 0.51 | 6.53 | 0.0062** | yes | 5.28 | 0.001*** |
VAL56, ILE101 | 2 | Grantham | 0.47 | 457.69 | 0.0069** | no | 5.28 | 0.001*** |
LYS117, GLU123, ARG127 | 3 | Grantham | 0.4 | 487.3 | 0.0076** | no | 15.43 | 0.004** |
PRO118, THR119 | 2 | Polarity | 0.47 | 18.47 | 0.0096** | no | 3.75 | 0.001*** |
ALA232, TYR234, GLU235 | 3 | Charge | 0.87 | 1.41 | 0.0098** | yes | 10.51 | 0.002** |
Legends are the same as in table 1. Only groups with a p-value lower than 1% are reported. A global false discovery rate (FDR) of 1% was used when correcting for multiple testing.