Table 5.

Correlation analysis results for the MAP data set.

PDB	Size	Weight	Stat.	Nmin	p-value	FDR	3D dist.	3D p-value
ARG147, ASP187	2	Unweighted	0.57	4.92	0***	yes	6.24	0.001***
ARG147, ASP187	2	Grantham	0.59	517.54	0***	yes	6.24	0.001***
ARG147, ASP187	2	Volume	0.58	384.76	3e-04***	yes	6.24	0.001***
GLN154, GLU158	2	Unweighted	0.65	4.93	0***	yes	5.96	0.001***‡
GLN154, GLU158	2	Charge	0.67	4.1	1e-04***	yes	5.96	0.001***‡
GLY122, LEU230	2	Unweighted	0.6	6.42	1e-04***	yes	7.44	0.002**‡
GLY122, LEU230	2	Grantham	0.6	590.32	1e-04***	yes	7.44	0.002**‡
GLY122, LEU230	2	Polarity	0.61	18.34	1e-04***	yes	7.44	0.002**‡
GLY122, LEU230	2	Volume	0.48	275.16	0.0052**	yes	7.44	0.002**‡
ALA21, LEU25, GLY107	3	Unweighted	0.45	4.09	1e-04***	yes	12.07	0.001***
LEU25, GLY107	2	Grantham	0.52	312.81	0.0077**	no	12.07	0.031*
THR241, GLY244	2	Unweighted	0.57	3.24	3e-04***	yes	5.11	0.001***
ASN46, SER68	2	Unweighted	0.48	4.67	5e-04***	yes	5.92	0.001***
GLY210, THR225	2	Unweighted	0.56	3.25	5e-04***	yes	8.28	0.004**
ASP219, TRP221, THR222, THR225, ASP227, GLU235, ILE238, THR241, LEU248	9	Grantham	0.3	68.81	6e-04***	yes	40.12	0.2338†
TRP221, THR222	2	Unweighted	0.57	2.73	0.0014**	yes	3.75	0.001***†
TRP221, THR225,	3	Volume	0.56	105.03	0.0092**	no	18.13	0.024*†
ASP227
LEU125, THR129	2	Unweighted	0.53	3.21	6e-04***	yes	6.12	0.001***
ASN208, SER231	2	Unweighted	0.48	4.32	7e-04***	yes	4.25	0.001***
TRP221, THR222, ALA232, GLU235, ILE238, VAL239, THR241, ILE247, LEU248	9	Polarity	0.28	2.15	0.001***	yes	34.73	0.025*
GLU148, GLU190	2	Unweighted	0.48	5.11	0.0011**	yes	11.88	0.03*
GLU148, GLU190	2	Polarity	0.5	13.91	0.006**	yes	11.88	0.03*
GLY210, GLY244, GLU246	3	Grantham	0.43	302.15	0.0012**	yes	33.45	0.4945
CYS78, ASN95, SER110, GLY150, GLN233	5	Unweighted	0.24	2.48	0.0018**	yes	21.37	0.001***
CYS169, GLN182	2	Unweighted	0.45	4.39	0.0018**	yes	6.4	0.002**
ILE96, TYR134	2	Unweighted	0.49	5.96	0.002**	yes	18.27	0.1768
ILE81, PHE113	2	Unweighted	0.45	4.33	0.0021**	yes	16.36	0.1259
ASP227, ALA232, GLU235	3	Unweighted	0.48	1.41	0.0022**	yes	23.49	0.0949.
ASP219, VAL223	2	Unweighted	0.46	3.66	0.0024**	yes	9.4	0.009**
HIS63, ARG127, GLN130, ALA209	4	Volume	0.33	205.12	0.0032**	yes	32.09	0.2527
HIS63, GLN130	2	Charge	0.47	5.36	0.0035**	yes	28.75	0.5994
THR222, SER231, ILE238, VAL239	4	Charge	0.71	0.99	0.0039**	yes	28.93	0.1199
ARG124, GLU131	2	Grantham	0.48	461.88	0.0043**	yes	10.6	0.016*
GLU131, VAL157, VAL164	3	Unweighted	0.36	4.39	0.0045**	yes	13.43	0.001***
GLN53, VAL98	2	Grantham	0.48	409.37	0.0049**	yes	13.51	0.0579.
GLU29, VAL32, ILE81, PRO82, THR129, ALA136, ILE149, GLY150, SER163	9	Polarity	0.21	0.1	0.005**	yes	32.31	0.008**
LEU135, PHE156	2	Grantham	0.49	575.88	0.0052**	yes	8.71	0.004**
GLN53, GLU160	2	Charge	0.44	5.85	0.0055**	yes	39.55	0.9311
VAL56, ILE101	2	Unweighted	0.51	6.53	0.0062**	yes	5.28	0.001***
VAL56, ILE101	2	Grantham	0.47	457.69	0.0069**	no	5.28	0.001***
LYS117, GLU123, ARG127	3	Grantham	0.4	487.3	0.0076**	no	15.43	0.004**
PRO118, THR119	2	Polarity	0.47	18.47	0.0096**	no	3.75	0.001***
ALA232, TYR234, GLU235	3	Charge	0.87	1.41	0.0098**	yes	10.51	0.002**

Legends are the same as in table 1. Only groups with a p-value lower than 1% are reported. A global false discovery rate (FDR) of 1% was used when correcting for multiple testing.