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. 2008 Jan 21;7:2. doi: 10.1186/1475-2891-7-2

Table 2.

List of possible causes and treatments for bipolar disorder including specific doses as well as supplementary information

Mental Disorder Proposed Cause Treatment References
Bipolar Disorder Food allergies Avoid foods that elicit an allergic response [76, 77]
Caffeine Avoid coffee and other caffeinated beverages [78]
Inhibition of lithium from alkalizing agents Avoid alkalizing agents like bicarbonates [79]
Vitamin B6 deficiency 100–200 milligrams/day [72, 80]
Vitamin B12 deficiency 300–600 mcirograms/day [71, 81–83]
Vitamin C deficiency 1–3 grams taken as divided doses [84–86]
Folate deficiency 200 micrograms/day [9, 13, 71, 82, 83, 87, 88]
Choline deficiency 10–30 grams of phosphatidyl form in divided doses [73, 89]
Omega-3 or -6 deficiency 500–1000 milligrams/day [10, 11, 21, 39, 74, 75, 90–94]
Phenylalanine deficiency Initially 500 milligrams/day; can increase to 3–4 grams/day [95, 96]
Tryptophan deficiency 50–200 milligrams taken as divided doses [97–100]
S-Adenosyl-L-Methionine (SAM) deficiency 800 milligrams [101–103]
Melatonin deficiency 3–6 milligrams at 9 pm [104–106]
Phosphatidylserine deficiency 100 milligrams with food [107]