Table 2.
Race-stratified mean total cholesterol, LDL-C, HDL-C, and TG concentrations according to LIPC, CETP, and LPL polymorphisms in White and African American men and women from the Atherosclerosis Risk in Communities (ARIC) study 1
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Hepatic Lipase C/T
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| White Participants (N = 8,897)
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African American Participants (N = 2,909)
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| Genotype Frequency 2 | CC 0.625 | CT 0.326 | TT 0.049 | P 5 | CC 0.219 | CT 0.505 | TT 0.276 | P 5 |
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| Total cholesterol (mg/dL) | 212.9 ± 0.5 | 213.9 ± 0.7 | 215.5 ± 1.9 | 0.28 | 211.9 ± 1.8 | 213.3 ± 1.2 | 214.7 ± 1.6 | 0.50 |
| LDL-C (mg/dL) | 136.6 ± 0.5 | 135.5 ± 0.7 | 133.8 ± 1.8 | 0.18 | 136.4 ± 1.7 | 136.5 ± 1.1 | 135.6 ± 1.5 | 0.89 |
| HDL-C (mg/dL) | 51.1 ± 0.22 | 53.3 ± 0.31 | 54.9 ± 0.81 | <0.001 | 54.7 ± 0.72 | 56.3 ± 0.47 | 58.7 ± 0.63 | <0.001 |
| TG (mg/dL) | 112.0 (110.5, 113.4) | 112.8 (110.8, 114.8) | 117.3 (112.0, 122.8) | 0.16 | 92.5 (89.2, 95.9) | 93.2 (91.0, 95.4) | 94.6 (91.7, 97.7) | 0.61 |
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Cholesteryl Ester Transfer Protein G/A
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| White Participants (N = 8,764)
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African American Participants (N = 2,795)
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| Genotype Frequency 3 | GG 0.326 | AG 0.478 | AA 0.196 | P 5 | GG 0.534 | AG 0.398 | AA 0.068 | P 5 |
| Total cholesterol (mg/dL) | 211.8 ± 0.7 | 213.8 ± 0.6 | 213.9 ± 1.0 | 0.069 | 213.8 ± 1.2 | 212.5 ± 1.4 | 215.4 ± 3.3 | 0.62 |
| LDL-C (mg/dL) | 136.6 ± 0.7 | 136.5 ± 0.6 | 134.1 ± 0.9 | 0.063 | 138.7 ± 1.1 | 134.0 ± 1.3 | 130.2 ± 3.2 | 0.003 |
| HDL-C (mg/dL) | 49.7 ± 0.3 | 52.0 ± 0.3 | 55.5 ± 0.4 | <0.001 | 54.4 ± 0.5 | 58.2 ± 0.5 | 64.2 ± 1.3 | <0.001 |
| TG (mg/dL) | 113.6 (111.5, 115.6) | 112.9 (111.3, 114.6) | 109.5 (107.0, 112.1) | 0.041 | 93.2 (91.1, 95.4) | 93.6 (91.1, 96.2) | 91.8 (86.0, 98.0) | 0.86 |
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Lipoprotein Lipase C/G
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| White Participants (N = 8,968)
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African American Participants (N = 2,677)
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| Genotype Frequency 4 | CC 0.806 | CG 0.185 | GG 0.010 | P 5 | CC 0.873 | CG 0.122 | GG 0.005 | P 5 |
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| Total cholesterol (mg/dL) | 213.3 ± 0.5 | 212.7 ± 1.0 | 213.8 ± 4.3 | 0.81 | 213.1 ± 0.9 | 214.6 ± 2.5 | 223.0 ± 12.3 | 0.63 |
| LDL-C (mg/dL) | 136.2 ± 0.4 | 135.3 ± 0.9 | 136.8 ± 4.0 | 0.65 | 136.1 ± 0.9 | 136.8 ± 2.4 | 137.9 ± 11.9 | 0.96 |
| HDL-C (mg/dL) | 51.4 ± 0.2 | 54.2 ± 0.4 | 55.4 ± 1.8 | <0.001 | 56.1 ± 0.4 | 59.2 ± 1.0 | 68.7 ± 4.9 | <0.001 |
| TG (mg/dL) | 114.7 (113.4, 116.0) | 104.2 (101.8, 106.7) | 97.9 (88.4, 108.5) | <0.001 | 94.6 (92.8, 96.3) | 85.5 (81.4, 89.9) | 78.0 (61.0, 99.7) | <0.001 |
Unadjusted values presented as mean ± SEM, with the exception of TG values which were log-transformed and back-transformed to the geometric mean (95% confidence interval).
T allele frequency = 0.212 and 0.529 in Whites and African Americans, respectively;
A allele frequency = 0.435 and 0.267 in Whites and African Americans, respectively;
G allele frequency = 0.102 and 0.066 in Whites and African Americans, respectively;
P for comparison among genotypes within each race group separately based on analysis of variance. P values for trend across genotype with genotype category treated as a continuous variable were nearly identical.