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. Author manuscript; available in PMC: 2008 Dec 1.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5445–5453. doi: 10.1167/iovs.06-1402

FIGURE 2.

FIGURE 2

Role of rhodopsin/arrestin complexes in Pro347Ser rhodopsin mutant degeneration. The ONL thickness of 4-month-old Pro347Ser rhodopsin mutant mice in the presence or absence of arrestin and transducin was plotted. The absence of α-transducin or arrestin alone did not contribute to degeneration (compare 3 left columns). Loss of α-transducin in combination with the Pro347Ser rhodopsin mutation produced a statistically significant loss of ONL thickness (columns 4 and 5). The combined loss of α-transducin and arrestin did not protect from degeneration (last column). Error bars show SEM.