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. Author manuscript; available in PMC: 2008 Dec 1.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5445–5453. doi: 10.1167/iovs.06-1402

FIGURE 4.

FIGURE 4

Comparison of A2E and A2E-precursor levels in (A) 61-day-old WT mice (gray) and littermate Pro347Ser, Trα+/+ transgenic mice (black) show statistically significant differences for four bis-retinoids. A2E was present at 4.8 versus 1 pmol/eye in Pro347Ser, Trα+/+ and WT mice, respectively. (B) Lipofuscin granule density. Four mice of each genotype were surveyed by measuring square microns of lipofuscin granule per square micron of RPE cytoplasm. P347S mutant mice (black) had a higher density of granules than WT control mice (gray). Error bars represent SD.