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. 2008 Feb 21;118(3):879–893. doi: 10.1172/JCI32865

Figure 3. Pretreatment with curcumin inhibits histone acetylation in vitro and in vivo.

Figure 3

(A and B) The dose and time courses of curcumin on the global acetylation of histones induced by PE. The results of 4 parallel experiments are shown. (C) Curcumin inhibited the acetylation of histone H3, histone H4, and tubulin. Experiments were performed in triplicate. The levels of histone H3 acetylation, histone H4 acetylation, and tubulin were quantified and normalized relative to GAPDH. *P < 0.05 versus control. (D and E) Curcumin blocked AB- and PE infusion–mediated acetylation of histone H3, histone H4, and tubulin in mice (n = 5). Densitometric quantification of acetyl-H3, acetyl-H4, and tubulin was normalized to GAPDH. *P < 0.05 versus respective vehicle control.