TABLE 2.
Life span and neuropathology of double mutants with ATPαDTS1
| 50% ± SD | Neuropathology | 50% ± SD | Neuropathology | |
|---|---|---|---|---|
| Genotype | +/+ | +/+ | DTS1/+ | DTS1/+ |
| +/Y | 38 ± 4.4 | 0–1 | 14 ± 0.8 | 4 |
| eas/Y | 35 ± 2.8 | 2 | 4 ± 0.8 | 2 |
| tko/Y | 31 ± 2.3 | 1–3 | 3 ± 0.6 | NA |
| sesB/Y | 26 ± 1.8 | 3 | 7 ± 0.4 | 2 |
| bss/Y | 23 ± 5.7 | 0–1 | 5 ± 0.6 | 0–1 |
| bas/Y | 23 ± 3.5 | 1–2 | 4 ± 0.5 | 0 |
| kdn/Y | 18 ± 1.7 | 0–1 | 11 ± 2.8 | 0–1 |
| +/+ | 38 ± 4.4 | 0–1 | 23 ± 3.4 | 4 |
| eas/+ | 44 ± 3.1 | 1 | 14 ± 6.0 | 4 |
| tko/+ | 48 ± 4.6 | 1 | 16 ± 6.4 | 3–4 |
| sesB/+ | 43 ± 7.8 | 2 | 27 ± 3.2 | 3–4 |
| bss/+ | 45 ± 1.0 | 1 | 15 ± 3.8 | 3–4 |
| bas/+ | 46 ± 5.3 | 0 | 24 ± 7.4 | 3 |
| kdn/+ | 44 ± 3.5 | 0–1 | 20 ± 6.2 | 2–4 |
The life span of males hemizygous for a bang-sensitive mutation (top) in combination with DTS1 is very reduced in comparison with heterozygous bang-sensitive females (bottom), which may not allow sufficient time for neurodegeneration to appear grossly as vacuolar brain lesions. Longevity (at 29°) is presented as the age in days at which 50% of the flies of the indicated genotype have died. Third chromosome genotype is indicated along the top. DTS1 is ATPαDTS1, a dominant temperature-sensitive ATPα allele. Neuropathology was scored 0 (none) to 5 (marked) at the median age. NA, not available.