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fH binding to meningococci via GNA1870 regulates the alternative pathway of complement. Strain H44/76 siaD lst and its isogenic mutant that lacked GNA1870 were incubated with NHS (15% v/v) and binding of IgG, C4, and C3 were measured by flow cytometry. Numbers beside each histogram indicate the geometric mean fluorescence of the entire population. Axes are as described in Fig. 1.
