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. Author manuscript; available in PMC: 2008 Feb 20.
Published in final edited form as: Drug Alcohol Depend. 2007 Oct 18;93(1-2):103–110. doi: 10.1016/j.drugalcdep.2007.09.002

Table 1.

Summary of Opioid Studies Analyzed

Study N Drug/Doses/Route MCP Range (# money values) UP Range (df) A parameter Mean (95% CI) Computed Pmax R2
1. Greenwald et al. (1999) 14 Hydromorphone 4, 8 and 16 mg IM (during maintenance on 2-8 mg/day SL buprenorphine) $0.25 – $20.00 (30) 0.016 – 5.0
 Heroin User 6 (32) 0.436 (0.396 – 0.477) b 0.665 0.92
 Heroin Non-User 8 (18) 1.772 (1.587 – 1.958) d 0.164 0.89
2. Greenwald and Hursh (2006) 13 Hydromorphone 12 and 24 mg IM (during maintenance on 8 mg/day SL buprenorphine) $0.25 – $25.00 (44) 0.010 – 2.08 (50) 0.518 (0.451 – 0.586) b 0.560 0.80
3. Greenwald (2005) 7 Fentanyl 0.25, 0.75 and 1.5 mg/70 kg IV (during maintenance 60-70 mg/day oral methadone) $0.50 – $30.00 (18) 0.33 – 120.0 (31) 0.031 (0.028 – 0.033) a 9.355 0.95
4. Greenwald (2006) 34 Methadone 28, 56 and 84 mg/day oral $1.00 – $100.00 (20) 0.012 – 3.57 (32) 0.871 (0.759 – 0.983) c 0.333 0.88
 Rapid Induction 18 (32) 0.846 (0.761 – 0.931) c 0.343 0.92
 Stepwise Induction 16 (30) 0.812 (0.718 – 0.905) c 0.357 0.90

Note: Different superscripts indicate that the “A” parameter values significantly differed (p < .05) based on F test.