Table 1.
Over-represented GO classes from the 'Molecular Function' and 'Biological Process' hierarchies observed among genes involved in fusion events
GO Molecular Function Class | Number of domains found | Domains with GO Annotation | Percentage in fusion events | Percentage in all domains | Log Odds Expectation |
receptor activity | 122299 | 720242 | 0.170 | 0.017 | 3.349 |
protein transporter activity | 180926 | 720242 | 0.251 | 0.029 | 3.120 |
small protein conjugating activity | 5566 | 720242 | 0.008 | 0.001 | 2.798 |
microtubule motor activity | 2780 | 720242 | 0.004 | 0.001 | 1.797 |
channel or pore class transporter activity | 11394 | 720242 | 0.016 | 0.009 | 0.832 |
transcription factor activity | 185303 | 720242 | 0.260 | 0.161 | 0.675 |
site-specific recombinase activity | 3732 | 720242 | 0.005 | 0.003 | 0.636 |
extracellular matrix structural constituent | 1242 | 720242 | 0.002 | 0.001 | 0.634 |
group translocator activity | 1742 | 720242 | 0.002 | 0.002 | 0.122 |
other classes | 205258 | 720242 | 0.285 | ||
GO Biological Process Class | |||||
cell communication | 25613 | 416772 | 0.061 | 0.010 | 2.674 |
regulation of cellular process | 48082 | 416772 | 0.115 | 0.055 | 1.068 |
regulation of development | 4082 | 416772 | 0.010 | 0.007 | 0.510 |
cellular physiological process | 34681 | 416772 | 0.083 | 0.059 | 0.493 |
regulation of physiological process | 205318 | 416772 | 0.493 | 0.356 | 0.468 |
other classes | 98996 | 416772 | 0.238 |