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Binding fraction for polyamides composed of imidazole- and pyrrole-type rings. (a) Binding to a sequence with 4-AT and 1-GC bp. (b) Binding to a sequence with 1-AT and 4-GC bp. The value for the optimal polyamide composed of pyrrole and imidazole rings, with imidazole placed next to each guanine and pyrrole next to adenine, cytosine, or thymine in the target sequence, is shown with an “X.”
