Figure 13.

Global kinetic modeling of Kv4.2 channel gating. In all panels, experimental data (black) and global best-fits (red) are shown for comparison. (A) Experimental currents (average of five independent experiments) were elicited by step depolarizations from −100 to +50 mV in 10-mV increments from a holding potential of −100 mV. Inset, an expanded view of the activation phase of the currents (−100 to +100 mV in 10-mV increments from a holding potential of −100 mV). (B) Experimental tail currents (average of three independent experiments) were evoked by test pulses between −140 and −50 mV after a depolarization to +50 mV. (C) Recovery from inactivation curves at the indicated voltages replotted from Fig. 5 C. (D) Experimental family of gating currents elicited by step depolarizations from −143 to +47 mV in 10-mV increments from a holding potential of −153 mV (top; average of five independent determinations) and corresponding best fit (bottom).