TABLE II.
Best-Fit Parameters of the ZHA + I Modela
| Rate constant (V = 0) | z | |
|---|---|---|
| s − 1 | e0 | |
| α1 | 1091.8 | 0.29 |
| β1 | 3299.5 | −1.23 |
| α2 | 5971.1 | 0.1 |
| β2 | 21.1 | −0.59 |
| γ | 9303.5 | 0.09 |
| δ | 2054.1 | −0.11 |
| κ1 | 103.9 | 0 |
| λ1 | 43.6 | 0 |
| κ2 | 29.5 | 0 |
| λ2 | 33.3 | 0 |
| kCI | 180.5 | 0 |
| kIC | 0.009 | 0 |
The rate constants that control the voltage-dependent transitions (α1, β1,α2, β2, γ, δ) are assumed to depend exponentially on membrane potential according to the relationships x(V) = x 0exp(z X eV/kT), where z x, is the corresponding equivalent electronic charges, e is the electronic charge, V is the membrane potential, k is Boltzmann constant, and T is the absolute temperature. The total gating charge per channel is 9 e0. The allosteric factor f is 0.42.
a
ZHA + I model as depicted in Fig. 12.