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(A) Three proposed models of NRIP gene regulation by AR and Sp1. (1) NRIP protein complexes AR which directly binds to the ARE site; (2) NRIP forms a complex with AR-Sp1 proteins through the AR protein, which indirectly binds to the Sp1 site of the NRIP promoter; (3) A loop forms between ARE and Sp1 sites of the NRIP promoter via the complex formation of AR-Sp1-NRIP. (B) NRIP feed-forward regulation activates its own expression and enhances AR-mediated PSA gene expression.
