Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2007 Nov 19;36(1):237–244. doi: 10.1093/nar/gkm1033

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2007 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 4. — Stability of the SEPN1uaa transcript under pathological or corrected conditions. SEPN1 mRNA levels were measured by quantitative PCR from nucleofected fibroblasts of a RSMD1 patient transfected either with tRNA^Secwt or tRNA^Secuua expression vectors. Scores were normalized to a HPRT control gene and levels were expressed as a percentage of the wild-type SEPN1 mRNA in fibroblasts from a control individual. The SEPN1uaa transcript was destablized, but transfection of the corrector tRNA^Secuua restored ∼60% of the SEPN1 wt mRNA level.