Figure 2.

Deduced amino acid sequence alignment of human (Hs) PEX1 protein and Pex1p from the yeasts Pichia pastoris (Pp) and Saccharomyces cerevisiae (Sc). A hyphen indicates a space. Amino acids identical between human and other species are shaded. Boxed are ATP/GTP-binding Walker motifs A (A-1 and A-2: A/GX₄GKS/T; X, any residue), motifs B (B-1 and B-2: R/K/HX_n>5ΦXΦ₂D/E; Φ, hydrophobic residue), and AAA-protein family signature (C: A/G/M/ΦXTXR/H/ΦXD/E/N/SXL/I/V/MDXAL/I/V/MXRXGRL/IV/M/Φ/YD/E), respectively. Open and solid arrowheads indicate the position of mutation in each allele from a CG-I patient, PBDE-04 (see Fig. 5A). The database accession number for the human PEX1 cDNA is AB008112.