TABLE 1.

Mutations in the VP7 gene and their effects on trimer and CLP stability

Helix, class, and no.	VP7 mutant	CLP stabilitya in:		No. of VP7/CLP (high salt)	Trimer forma- tion
		No salt	High salt
Helix 2
Class I
I	V24S/A27P	+++	++++	600	Yes
II	L45N/G47S	+++	++++	600	Yes
III	T53Q	+++	++++	600	Yes
Class II
IV	V24D/A27P	+	+++	420	Yes
V	V24D/A27P/N28E	++	+++	420	Yes
VI	L45K/G47D	−	+	60	Yes
VII	T53R	−	+	60	Yes
Class III
VIII	R22E	+	+	60	Yes
IX	M30R	++	+++	420	Yes
X	N38D	−	−		Yes
XI	L33S/G34S/I35S/A36S	−	−
Helix 9
XII	G337Q	+++	++++	600	Yes
XIII	P338Q	+	++	420	Yes
XIV	A342R	+++	++++	600	Yes
XV	A346R	+	++	420	Yes
XVI	G337Q/P338Q	−	+	60	Yes
XVII	A342R/A346R	−	+	60	Yes