TABLE 3.
Presence of consensus transcription factor binding sites in the −500 to −1 promoter sequence
| Binding site | Upregulated genes
|
Downregulated genes
|
||||
|---|---|---|---|---|---|---|
| Matcha | % | Genes | Match | % | Gene symbol | |
| E2F | 15/33 | 45 | ADAMTS1, CDC25A, CTSD, FZD8, GEMIN4, HNRPK, HSPA1L, MGC2555, NR4A1, NUP1P1, POLR2A, POMCP3, SNAI1, SZF1, TNKS1BP1 | 4/18 | 22 | BTBDR, CARF, CCND1, SSB |
| CREB | 15/33 | 45 | C18B11, CTSD, FUT1, ELK4, HSPA1L, MRPS25, NR4A1, NUF1P1, P2RX5, POMCP3, SZF1, TLE3, TNKS1BP1, TP53TG1, VPS28 | 5/18 | 28 | ID3, IL6, RNF19, SDPR, TNFAIP3 |
| STAT | 4/33 | 12 | COL6A1, GADD45B, SZF1, TP53TG1 | 8/18 | 44 | BMP4, CCL2, CCND1, CKTSF1B, CXCL1, F3, FBXO32, GAS1 |
| C/EBPβ | 6/33 | 18 | ADAMTS1, ATF3, C18B11, MRPS25, PGA5, POLR2A | 6/18 | 33 | BMP4, FBXO32, IL6, RNF19, SSB, SDPR |
| NF-κB | 6/33 | 18 | GADD45B, PGA5, POLR2A, SMURF1, SNAI1, VSP28 | 6/18 | 33 | CCL2, CKTSF1B, CXCL1, F3, IL6, TNFAIP3 |
a
The number of genes out of the total number of genes analyzed belonging to the category of up- or downregulated genes where one or more consensus transcription factor binding site was identified.